|Notable Members||Hulk, A-Bomb, Red Hulk, She-Hulk, Skaar, Devil Dinosaur|
|Goal||To Tackle Threats No Other Superheroes Can Face.|
|Location||Hulk Gamma Base|
|First appearance||Doorway to Destruction, Part 1|
The Hulk has long fought alone to protect a world that only sees him as a monster, but his best friend Rick Jones has taken it upon himself to film the world-saving exploits of Big Green and his team to change that image. In this never before seen team up of Hulk, his cousin She-Hulk, A-Bomb, Red Hulk and Skaar, Marvel's mightiest super heroes form an eccentric family living under one roof, working together to tackle threats that are too enormous for other heroes to handle them. From trying to housebreak their giant red pet T-Rex to stopping Ego the Living Planet from crashing into the Earth, the Agents of S.M.A.S.H. must learn to balance their Hulk-sized actions with their everyday family-sized problems. Hulk always sees this team as a gamma family to him.
- Hulk (Bruce Banner): The Hulk is the biggest, strongest, smashing-est hero there is - the green glue that holds his crazy family-like team together.Hulk loves saving the world by smashing every alien, sea creature, and planet (literally) that tries to destroy it. He is the star of his best bud A-Bomb's web series, and just wants to show people his good intentions!
- Red Hulk (Thunderbolt Ross): US Army General Thunderbolt Ross used to a be a huge pain in Hulk's you know what! But as the saying goes, if you can't beat 'em, join 'em! He decided to supersize himself and join the team as Red! Just as cranky as before, Red still gives Hulk a hard time, but deep down he loves being a part of the Agents of S.M.A.S.H. - that, and his Gatling Laser Cannon.
- A-Bomb (Rick Jones): Rick Jones has been Hulk's best bud since day one, but now he's more than a friend. He's a teammate! Transformed by a Gamma energy explosion, A-Bomb's thick, armored skin is just as strong and powerful as it is blue. And when he curls into action, he uses it like a giant bowling ball of destruction!
- She-Hulk (Jennifer Walters): She-Hulk is the Hulk's action-loving cousin. She's unbelievably strong, pilots the group's heavily armed Jump Jet, and uses a pair of Gamma Gauntlets that give her fists an added energy wallop. As the most competitive member of the team, She-Hulk never backs down from a fight, arm-wrestling match, or burping contest!
- Skaar: No one knows where Skaar, the savage sword-swinger, came from, but one thing is for sure...he's a Hulk. The intensity of Skaar’s war cry "Skaar Slash!" is matched only by his ferocious appetite. Although he is a great asset in the fight against evil, Skaar is just as destructive at home as he is on the battlefield.
- Devil Dinosaur: The red titan known as Devil Dinosaur is an ally as much as a pet. After A-Bomb's first visit to the Savage Land, he and Red were attacked by the colossal carnivore while it was under Sauron's mind control. After swallowing A-Bomb, and Hulk making him spit A-Bomb up, Devil was freed from Sauron's control and took a liking to the Gamma powered goliaths. However, now that he's their pet, A-Bomb has some trouble getting him House Broken.
- The Avengers
- Fantastic Four
- Iron Man
- Captain America
- Guardians of the Galaxy
- Howling Commandos
- Ghost Rider
- Silver Surfer
- Betty Ross
- Doctor Strange
- The Leader
- Ronan the Accuser
- The Collector
- Wrecking Crew
- Doctor Octopus
- Supreme Intelligence
- Doctor Doom