|Notable Members||Ymir, Loki|
|Goal||Conquest of the Nine Realms|
|First appearance||Hulks On Ice|
Frost Giants are a race of beings from Jotunheim. They are at a constant state of war with the Asgardians. The giants have shown the ability to manipulate ice as projectiles, balls, and more. They are also vastly strong and durable.
Laufey led the Frost Giants in a plot to take over the Nine Worlds. Upon confronting Laufey, the Agents of S.M.A.S.H. and Thor end up subdued by the cold winds and captured. Laufey arrived revealing his plot and even commented that he doesn't know what Thor sees in the humans. She-Hulk broke free from the ice and freed Thor and the Hulks as Laufey gets away. After defeating the three-headed Ice Serpent, the Agents of S.M.A.S.H. and Thor arrive at Laufey's lair as Laufey unleashes his ice creatures on them. Following the plug-up of the ice, Laufey stated that they have helped to free Ymir who will help bring an endless winter to Earth. Ymir then attacks Thor and the Hulks as they work to defeat Ymir. When Skaar tried to repeatedly stab Ymir, he froze Skaar who was caught by A-Bomb before he can hit the ground. Thor told Hulk that they will have to find Ymir's weak spot. Skaar's sword was left in Ymir as the Hulk's act as they attacked the weak spot. Before Ymir can hit A-Bomb, She-Hulk gets both of them out of the way. Thor comes up with a plan where he and Hulk attack Red Hulk enough to heat him up and throws him towards Ymir which cracks up Ymir. Thor then fires his lightning which shatters Ymir as Laufey retreats back to Jotunheim.
Hulk follows The Leader back in time to the Viking Age where they are apprehended by a young Thor and Loki who accuse them of trying to steal the fragments of the Berserker Staff. When Odin goes into his Odinsleep, Hulk teams up with Thor and Loki to keep Leader from taking the Asgardian throne from Odin. In the present, the Agents of S.M.A.S.H. fight to stop "All Father" Leader from taking over the planet with Thor and Loki in his services as well as an army of Gamma Frost Giants.