|Notable Members||Invisible Woman, Human Torch, The Thing|
|Location||Baxter Building, New York|
|First appearance||Monsters No More|
The Fantastic Four are a team of adventurers and super-heroes. During an accident on an experimental rocket, they were all given fantastic powers through exposure to cosmic rays.
The Thing hosts a poker game at the Baxter Building against Hulk, Red Hulk and She-Hulk. He is captured alongside them and is taken by The Collector to be a part of his collection. The Agents of S.M.A.S.H. and Spider-Man free him along with the other heroes.
Hulk travelled to the Baxter Building in New York to use the Fantastic Four's Negative Zone portal. When Hulk and Thing enter the Negative Zone, Hulk and Thing end up fighting Blastaar at Leader's lair. Annihilus is seen with the Leader where it was shown that Leader had confiscated Annihilus' Cosmic Control Rod and modified it. Blastaar was defeated by Thing while the Hulk battled the Leader. After Leader was defeated by Hulk, Annihilus reclaimed the Cosmic Control Rod and escaped.While Hulk was fighting Leader.
- Mister Fantastic (Reed Richards), a scientific genius and the leader of the group, who can stretch his body into incredible lengths and shapes;
- Invisible Woman (Susan "Sue" Storm), who eventually married Reed, who can render herself invisible and later project powerful force fields;
- Human Torch (Johnny Storm), Sue's younger brother, who can generate flames, surround himself with them and fly; and
- The Thing (Ben Grimm), their grumpy but benevolent friend, a former college football star and Reed's college roommate as well as a good pilot, who possesses superhuman strength and endurance due to the nature of his stone-like flesh.